REPRODIVAC - Next-generation vaccines and diagnostics to prevent livestock reproductive diseases of worldwide impact
First steps successfully undertaken on the path to develop novel vaccines designed to elicit antibodies that broadly neutralise PRRS viruses
Lorenzo Fraile and colleagues from University of Lleida recently hosted Simon Graham and Jane Edwards from The Pirbright Institute.
They worked together to isolate and cryopreserve large numbers of B cells from the blood and lymph nodes of sows that they had shown to posses serum antibodies that broadly neutralise PRRS viruses.
These cells have now been shipped to Pirbright where they will be used to isolate monoclonal antibodies.
These antibodies will then be supplied to other REPRODIVAC partners to define highly conserved neutralising epitopes on the PRRS virus, which will enable the design of vaccines that should provide broad protection.